Promote Osseointegration Through Surface Functionalization of Ti-Zr Alloy by Nano Composite Fiber

Using bioactive and biocompatible coatings to biofunctionalized metallic implant surfaces for enhanced bone regeneration while resisting bacterial infection has attracted materials scientists' interest. Bio-metallic Ti-25Zr disc sample was prepared using powder metallurgy then coated an electrospinning method form a nanocomposite fiber as coating layer over the surface of metal alloy substrate. Three nano-compounds (Nano-hydroxyapatite, Nano-Titanium dioxide, Nano-strontium titanite) were added individually Polycaprolactone/Chitosan blend prepare solutions. The results show significant improvement in biocompatibility samples after seven days (MC3T3-E1) cell culture. Cell viability percentages significantly higher compared uncoated ones, with values PCL/Chitosan/nHA (HA1) 239.45±17.95%, PCL/Chitosan/nSrTiO3 (SR1) has170.09±8.12%, PCL/Chitosan/nTiO2 (TI1) 117.19±19.42%, bare 80.52±1.97%. proliferation also shows remarkable increase time samples, enhancement reaches 197.76% (HA1), 111.38% (SR1), 45.81 % comparison (bare Ti-25Zr). For antibacterial test, no inhibition zone control Ti-25Zr) observed, showed suitable comparable zone. procedure is simple inexpensive, composite nano-fiber high promise orthodontic orthopedic regeneration.